Anti-bacterial activities of xanthones from mangoesteen

ฤทธิ์ต้านจุลินทรีย์ของสารแซนโธนส์จากมังคุด

Assoc. Prof. Dr. Souwalak Phongpaichit

Natural Products Research Center, Department of Microbiology, Mangosteen Research and Development Center, 

Asian Phytoceuticals Public Co., Ltd.

Wilawan Mahabusarakam

Natural Products Research Center, Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

Metta Ongsakul

Department of Microbiology, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

โสภา คำมี

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

World health problems caused by drug-resistant bacteria are increasing. Methicillin-

resistant Staphylococcus aureus (MRSA) has become a major pathogen causing hospital 

and community acquired infections. MRSA infections are more difficult to treat due to 

the antibiotic-resistance of the bacteria. GM-1 and GM-3, major xanthones from 

mangosteen (Garcinia mangostana) exhibited antibacterial activity against MRSA 

comparable to a standard drug vancomycin. Mangosteen xanthone cream can effectively 

treat skin infection as compared with commercial antibiotics. In addition, these 

xanthones inhibited the growth of Enterococcus sp.