Anti-inflammation of xanthones from mangoesteen

ฤทธิ์ต้านการอักเสบของสารแซนโธนส์จากมังคุด

Assoc. Prof. Dr. Ampai Panthong

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 

and Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

Xanthones in mangosteen posses anti-inflammatory activity and the most active one is 

GM-1. The detailed study of GM-1 for its anti-inflammation and analgesia showed that 

GM-1 exhibited stronger anti-inflammatory activity three times over that of aspirin as 

seen in carrageenin-induced rat paw edema, rat pleurisy and on the primary lesion of 

adjuvant-induced arthritis models. In addition GM-1 also showed inhibitory activity in 

chronic inflammation as found in cotton pellet-induced granuloma formation and on the 

secondary lesion of adjuvant-induced arthritis in rats. Furthermore GM-1 elicited 

analgesic effect when tested in acetylcholine-induced writhing response in mice. The 

investigation of analgesic effect of the products from mangosteen (as food supplement) 

in volunteers with joint pain and gastric ulcer will also be presented.