Antioxidation and antimalarial activities of xanthones from mangoesteen

ฤทธิ์ต้านปฏิกิริยาออกซิเดชั่นและฤทธิ์ต้านมาเลเรียของสารแซนโธนส์จากมังคุด

Assoc. Prof. Dr. Wilawan Mahabusarakam

Department of Chemistry, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

Dr. Metta Ongsakul

Department of Microbiology, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

นงพร โตวัฒนะ

Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hatyai, 

Songkhla, Thailand

ประพนธ์ วิไลรัตน์

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

In cardiovascular disease, it has been generally accepted that oxidative modification 

of LDL plays a critical role in atherosclerosis. Therefore, antioxidants able to 

interfere with lipid peroxidation may be beneficial in reducing atherogenic process. 

GM-1, a major xanthone in the fruit hulls of Garcinia mangostana, was shown for the 

first time to be a free radical scavenger protecting the LDL from oxidative damage in 

vitro in 1995. Some years later, a series of GM-1 derivatives were prepared and then 

tested for their activities on LDL oxidation. Some of them exhibited more profound 

effects than GM-1 itself. Therefore, some structural modifications of GM-1 are capable 

of enhancing its antioxidant activity.

GM-1 and its derivatives have also been shown to be antiplasmodial, antioxidant, and 

inhibiting eukaryote protein kinases and cyclic nucleotide-binding phosphatase.