Molecular investigation on anti-cartilage degradation by xanthones from mangoesteen

กลไกการออกฤทธิ์ยับยั้งการเสื่อมสลายของกระดูกอ่อนของสารแซนโธนส์จากมังคุด

Assoc. Prof. Dr. Prachya Kongtawelert

Thailand Excellence Center for Tissue Engineering, Department of Biochemistry, 

Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., and

Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

Asst. Prof. Dr. Siriwan Ongchai

Thailand Excellence Center for Tissue Engineering, Department of Biochemistry, 

Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., and

Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

Osteoarthritis (OA) is the most common form of arthritis. It results from an imbalance 

between predominantly chondrocyte-controlled anabolic and catabolic processes, and is 

characterized by progressive degradation of the components of the extracellular matrix 

(ECM) of the articular cartilage, associated with secondary inflammatory factors.

The effect of xanthones from mangosteen on the cartilage degradation in vitro and 

human chondrocyte culture was investigated. GM-1 was found to be the most active, 

comparable to or even better than the drugs presently prescribed for osteoarthritis. 

The detail of this findings together with the molecular mechanism and mode of action 

will be presented.